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KMID : 0043320030260020124
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Archives of Pharmacal Research
2003 Volume.26 No. 2 p.124 ~ p.127
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Bioactive Prenylated Flavonoids from the Stem Bark of Artocarpus kemando
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Seo EK
Lee DH/Shin YG/Chai HB/Navarro HA/Kardono LBS/Rahman I/Cordell GA
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Abstract
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Four known prenylated flavonoids, artonins E (1) and 0 (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as momtors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic
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